Cholestyramine dietary changes, it reduces low density lipoprotein (LDL)

 

Cholestyramine is
prescribed most of the time along with dietary changes, it reduces low density
lipoprotein (LDL) and the total cholesterol. LDL is a lipid that is found in
your blood, some people call it the “bad cholesterol”.  High levels of LDL have been linked to heart
disease, this medication helps lower level of LDL and raise HDL (the good
cholesterol). This medication works by removing the bile acid from the body, it
attaches to the bile acids found in the intestine and both are eliminated from
the body as waste.

Lovastatin works by
decreasing the quantity of cholesterol made by the liver, it inhibits
3-hydroxy-3-methylglutaryl-coenzyme. That is where they get the name of HMG-CoA
inhibitors.

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Once this enzyme is
blocked, LDL levels decreases as more LDL is absorbed by the cells for the
process of cholesterol.

The most common adverse effects
from lovastatin are GI related issues such as abdominal cramps, nausea,
vomiting, flatulence and constipation. Rhabdomyolysis can occur as well, this
condition causes muscle to breakdown, causing injury to the glomerulus and
resulting in acute kidney failure. Signs of this condition are dark-colored
urine, diarrhea, a fever, muscle cramps or spasms, muscle stiffness, and
feeling very tired or weak. Liver failure can also occur, some sign and
symptoms are headache, stomach ache, vomiting, dark colored urine, weight loss,
light-colored stools, upper right stomach pain, and yellowing of eyes or skin.
Patient teaching is very important so the client can be able to recognize these
signs and symptoms and reported it right away to avoid further complications or
worsening of the condition.

 

A person taking this drug
should avoid drinking grapefruit juice, it can lead to increased serum level of
the drug and increase the risk of developing an adverse reaction.

Lipids have different
forms of fat in the body and cholesterol types. In order to measure if lovastatin
is being effective we can do a lipid panel. Which it would measure; total
cholesterol, HDL, LDL, and Triglycerides. 

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